新萄京网站 >科研队伍 >研究员

研究员

姓名 许杰 性别
专家类别
学历 博士 职称 研究员
联系电话 021-53882357 电子邮箱 jiexu@yahoo.com
通讯地址 上海市黄浦区山东中路145号综合楼1021室
个人概况

许杰,研究员,博士毕业于比利时布鲁塞尔自由大学,归国后在上海交通大学医学院附属仁济医院开展肿瘤发生机制与转化研究。入选了国家自然科学基金优青、万人计划青年拔尖人才、浦江人才、曙光学者、东方学者、青年科技启明星等人才计划。以独立通讯编辑发表在Nature Chemical Biology, Nature Biomedical Engineering, Cell Chemical Biology,Oncogene, Oncoimmunology, Frontiers in Immunology等期刊,另外以共同通讯编辑在Gut,JNCI, Cancer Research, Nature Communications, Cell Reports, Oncogene等期刊发表论文。以第一发明人申请6项专利。获得上海市卫生系统银蛇奖二等奖(2015年),以第4完成人获得2018年国家科技进步二等奖。

研究方向

专注于消化系统肿瘤发生机制与生物治疗靶点的研究,特别是在PD-1/PD-L1肿瘤免疫检查点和p53抑癌通路开展转化研究:①发现了HIP1R介导的PD-L1溶酶体降解途径,并在识别HIP1R关键功能序列的基础上设计PD-LYSO多肽用于降解PD-L1,提供了区别于现有抗体药物的新靶向策略;②揭示PD-L1的棕榈酰化修饰促进其表达的机制,并在此基础上开发了PD-Palm分子,证明PD-L1的棕榈酰化为新的有效靶点;③发现Morn3癌睾丸抗原通过抑制p53而促进直肠癌发生的机制,设计Morncide多肽用于阻断Morn3的功能并在动物模型中显示抗癌活性。


科研论文

1.      Wang, Huanbin(#); Yao, Han; Li, Chushu; Shi, Hubing; Lan, Jiang; Li, Zhaoli; Zhang, Yao; Liang, Lunxi; Fang, Jing-Yuan; Xu, Jie(*), HIP1R targets PD-L1 to lysosomal degradation to alter T cell-mediated cytotoxicity. Nature Chemical Biology, 2019.1, 15(1): 42~50

2.      Han Yao(#); Jiang Lan(#); Chushu Li(#); Hubing Shi(#); Jean-Philippe Brosseau; Huanbin Wang; Haojie Lu; Caiyun Fang; Yao Zhang; Lunxi Liang; Xiaolin Zhou; Chaojun Wang; Yu Xue; Yun Cui; Jie Xu(*), Inhibiting PD-L1 palmitoylation enhances T-cell immune responses against tumours, Nature Biomedical Engineering, 2019 May;3(5):414

3.      Liang, Lunxi(#); Wang, Huanbin(#); Yao, Han; Li, Chushu; Zhang, Yao; Wang, Jilin; Wang, Yingchao; Zhao, Shuliang; Qian, Jin; Chen, Yingxuan; Fang, Jing-Yuan; Xu, Jie; Shi, Hubing; Xiang, Dabin; Shi, Hubing; Xiang, Dabin; Shi, Hubing; Xiang, Dabin; Li, Zhaoli; Bu, Zhigao; Song, Ningning; Hu, Ye; Xu, Qi; Ma, Yanlei; Cheng, Zhongyi; Xu, J(*), A Designed Peptide Targets Two Types of Modifications of p53 with Anti-cancer Activity, Cell Chemical Biology, 2018.06.21, 25(6): 761~774

4.      Wang, Huanbin(#); Yao, Han(#); Li, Chushu; Liang, Lunxi; Zhang, Yao; Shi, Hubing; Zhou, Chongzhi; Chen, Yingxuan; Fang, Jing-Yuan; Xu, Jie(*), PD-L2 expression in colorectal cancer: Independent prognostic effect and targetability by deglycosylation, Oncoimmunology, 2017, 6(7): e1327494

5.      Zhang, Y.(#); Hu, Y.(#); Wang, J-L; Yao, H.; Wang, H.; Liang, L.; Li, C.; Shi, H.; Chen, Y.; Fang, J-Y; Xu, J.(*), Proteomic identification of ERP29 as a key chemoresistant factor activated by the aggregating p53 mutant Arg282Trp, Oncogene, 2017.9.28, 36(39): 5473~5483

6.      Yao, Han(#); Wang, Huanbin; Li, Chushu; Fang, Jing-Yuan; Xu, Jie; Xu, J(*), Cancer Cell-intrinsic PD-1 and implications in Combinatorial immunotherapy, Frontiers in Immunology, 2018.07.30, 9(1774): 0~1774

7.      Wang H(#); Liang L; Fang JY; Xu J(*), Somatic gene copy number alterations in colorectal cancer: new quest for cancer drivers and biomarkers, Oncogene, 2015.01.01, 35(304): 2011~2019  

8.      Yao Zhang(#); Samya Van Coillie; Jing-Yuan Fang; Jie Xu(*), Gain of function of mutant p53: R282W on the peak?, Oncogenesis, 2016, 5(2): e196  

9.      Xie, Yuan-Hong(#); Gao, Qin-Yan; Zou, Tian-Hui; Chen, Hui-Min; Yu, Si-Yi; Qiu, Yi-Wen; Gu, Wei-Qi; Chen, Xiao-Yu; Cui, Yun; Sun, Danfeng; Xu, Jie; Chen, Ying-Xuan; Fang, Jing-Yuan; Cai, Guo-Xiang; Cai, San-Jun; Sun, Xiao-Ming; Liu, Zhan-Ju; Cai, SJ(*); Xu, J(*); Chen, YX(*); Fang, JY(*), Fecal Clostridium symbiosum for Noninvasive Detection of Early and Advanced Colorectal Cancer: Test and Validation Studies, EBioMedicine, 2017.11, 25: 32~40

10.   Qian, Jin(#); Kong, Xuan(#); Deng, Niantao; Tan, Patrick; Chen, Haoyan; Wang, Jilin; Li, Zhaoli; Hu, Ye; Zou, Weiping; Xu, Jie(*); Fang, Jing-Yuan(*), OCT1 is a determinant of synbindin-related ERK signalling with independent prognostic significance in gastric cancer, Gut, 2015.1.01, 64(1): 37~48  

11.   Liang L(#); Fang JY(*); Xu J(*), Gastric cancer and gene copy number variation: emerging cancer drivers for targeted therapy, Oncogene, 2015.01.01, 35(12): 1475~1482

12.   Wang, Jilin(#); Qian, Jin(#); Hu, Ye; Kong, Xuan; Chen, Haoyan; Shi, Qinghua; Jiang, Long; Wu, Chenming; Zou, Weiping; Chen, Yingxuan; Xu, Jie(*); Fang, Jing-Yuan(*), ArhGAP30 promotes p53 acetylation and function in colorectal cancer, Nature Communications, 2014.08.26, 5: 5735

13.   Hu, Ye(#); Wang, Jilin; Qian, Jin; Kong, Xuan; Tang, Jieting; Wang, Yingchao; Chen, Haoyan; Hong, Jie; Zou, Weiping; Chen, Yingxuan; Xu, Jie(*); Fang, Jing-Yuan(*), Long Noncoding RNA GAPLINC Regulates CD44-Dependent Cell Invasiveness and Associates with Poor Prognosis of Gastric Cancer, Cancer Research, 2014.12.1, 74(23): 6890~6902

14.   Xiaolin Zhou(#)(*); Jie Xu(*), Identification of Alzheimer's disease–associated long noncoding RNAs, Neurobiology of aging, 2015.01.01, 36(11): 2925~2931  

15.   Wang, J-L(#); Chen, Z-F(#); Chen, H-M(#); Wang, M-Y; Kong, X.; Wang, Y-C; Sun, T-T; Hong, J.; Zou, W.; Xu, J.(*); Fang, J-Y(*), Elf3 drives beta-catenin transactivation and associates with poor prognosis in colorectal cancer, Cell Death & Disease, 2014.5, 5(5): e1263

16.   Chen, Haoyan(#)(*); Xu, Jie(*); Hong, Jie; Tang, Ruqi; Zhang, Xi; Fang, Jing-Yuan(*), Long noncoding RNA profiles identify five distinct molecular subtypes of colorectal cancer with clinical relevance, Molecular Oncology, 2014.12, 8(8): 1393~1403  

17.   Xu, J.(#)(*); Wang, J.(#); Hu, Y.; Qian, J.; Xu, B.; Chen, H.(*); Zou, W.; Fang, J-Y(*), Unequal prognostic potentials of p53 gain-of-function mutations in human cancers associate with drug-metabolizing activity, Cell Death & Disease, 2014.3, 5(3): e1108  

18.   Xu J, Reumers J, Couceiro JR, De Smet F, Gallardo R, Rudyak S, Cornelis A, Rozenski J, Zwolinska A, Marine JC, Lambrechts D, Suh YA, Rousseau F(*), Schymkowitz J(*). Gain of function of mutant p53 by coaggregation with multiple tumor suppressors. Nature Chemical Biology. 2011 May;7(5):285-95


科研项目

1.    国家重点研发计划“精准医学研究”课题,2016YFC0906002,结直肠癌精准靶向治疗新靶点的高通量功能性筛选以及分子作用机理研究, 2016-07~2020-12,295万元,在研,主持

2.    国家自然科学基金面上项目,81572326,RNA解旋酶DHX33调控p53蛋白的乙酰化和抑制肿瘤增值的机制,2016-01~2019-12,68万元 ,在研,主持

3.    国家自然科学基金创新研究群体,81421001,肠稳态影响慢性重大肠肝疾病的发生与预防,2015-01~2020-12,100万元 ,在研,参加(排名第4)

4.    中组部“万人计划”青年拔尖人才,组厅字[2015]48号,自然科学类项目,2015-12~2018-11,190万元 ,已结题,主持

5.    上海交通大学医学院高峰高原计划,20152514,临床专职科研队伍项目,2015-01~2017-12,100万元 ,已结题,主持

6.    国家科技支撑计划,2015BAI13B07,临床医学研究(消化疾病)协同网络建设示范应用研究,2015-04~2017-12,42万元 ,已结题,参加

7.    上海市“东方学者”特聘教授,沪教委人(2013)70 号,消化道肿瘤相关的异常蛋白质相互作用,2014-01~2016-12,100万元 ,已结题,主持

8.    国家自然科学基金优秀青年科学基金,81322036,消化系统肿瘤发生,2014-01~2016-12,100万元 ,已结题,主持


获得专利
实验室成员

工作人员

姚晗,博士后

研究生

王焕彬,博士研究生

李楚舒,博士研究生

王一婷,博士研究生

章瑶,博士研究生(已毕业)

梁纶熙,硕士研究生(已毕业)

image002_副本.jpg

ICP备案号:沪ICP备15036656号-1 版权所有:新萄京网站
XML 地图 | Sitemap 地图